Covalent Libraries

Covalent binder libraries for challenging and undruggable targets, featuring warhead-focused, residue-specific, and target-selective screening sets.

AQura Bio. provides an advanced suite of covalent binder libraries engineered for the selective interrogation of both established and emerging "undruggable" targets. These collections  include warhead-focused sets - acrylamides, chloroacetamides, boronic acids - alongside residue-selective libraries targeting Cys, Ser, and Lys nucleophiles, as well as target-tailored sets such as M-pro binders.

Each library is designed using structure-guided principles, electrophile reactivity profiling, and chemotype diversity analysis to ensure controlled covalent engagement, optimal selectivity windows, and downstream tractability for lead optimisation. Built for high-confidence screening, AQura Bio’s covalent libraries enable precise mapping of ligandable residues and accelerate the discovery of next-generation covalent therapeutics.

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